WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for the enriched GO category are listed in this table. For each GO category, the first row lists its sub-root (biological process, molecular function, or cellular component), category name, and corresponding GO ID.
The second row lists the following statistics:
Finally, genes in the category are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:biological process       Name:fatty acid metabolic process       ID:GO:0006631
C=282; O=11; E=0.42; R=25.94; rawP=6.57e-14; adjP=2.23e-11
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000005882 NA PDK2 pyruvate dehydrogenase kinase, isozyme 2 5164 ENSG00000005882
2  ENSG00000134824 NA FADS2 fatty acid desaturase 2 9415 ENSG00000134824
3  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
4  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
5  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
6  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
7  ENSG00000072310 NA SREBF1 sterol regulatory element binding transcription factor 1 6720 ENSG00000072310
8  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
9  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
10  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
11  ENSG00000178537 NA SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 788 ENSG00000178537


Database:biological process       Name:lipid oxidation       ID:GO:0034440
C=92; O=8; E=0.14; R=57.83; rawP=5.33e-13; adjP=4.53e-11
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
2  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
3  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
4  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
5  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
6  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
7  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
8  ENSG00000178537 NA SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 788 ENSG00000178537


Database:biological process       Name:cellular lipid metabolic process       ID:GO:0044255
C=813; O=14; E=1.22; R=11.45; rawP=5.07e-13; adjP=4.53e-11
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000121691 NA CAT catalase 847 ENSG00000121691
2  ENSG00000005882 NA PDK2 pyruvate dehydrogenase kinase, isozyme 2 5164 ENSG00000005882
3  ENSG00000134824 NA FADS2 fatty acid desaturase 2 9415 ENSG00000134824
4  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
5  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
6  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
7  ENSG00000166821 NA PEX11A peroxisomal biogenesis factor 11 alpha 8800 ENSG00000166821
8  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
9  ENSG00000072310 NA SREBF1 sterol regulatory element binding transcription factor 1 6720 ENSG00000072310
10  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
11  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240
12  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
13  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
14  ENSG00000178537 NA SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 788 ENSG00000178537


Database:biological process       Name:fatty acid oxidation       ID:GO:0019395
C=89; O=8; E=0.13; R=59.78; rawP=4.06e-13; adjP=4.53e-11
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
2  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
3  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
4  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
5  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
6  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
7  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
8  ENSG00000178537 NA SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 788 ENSG00000178537


Database:biological process       Name:oxidation-reduction process       ID:GO:0055114
C=558; O=12; E=0.84; R=14.30; rawP=3.85e-12; adjP=2.18e-10
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000121691 NA CAT catalase 847 ENSG00000121691
2  ENSG00000132825 NA PPP1R3D protein phosphatase 1, regulatory subunit 3D 5509 ENSG00000132825
3  ENSG00000134824 NA FADS2 fatty acid desaturase 2 9415 ENSG00000134824
4  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
5  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
6  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
7  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
8  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
9  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
10  ENSG00000044446 NA PHKA2 phosphorylase kinase, alpha 2 (liver) 5256 ENSG00000044446
11  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
12  ENSG00000178537 NA SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 788 ENSG00000178537


Database:biological process       Name:monocarboxylic acid metabolic process       ID:GO:0032787
C=406; O=11; E=0.61; R=18.02; rawP=3.52e-12; adjP=2.18e-10
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000005882 NA PDK2 pyruvate dehydrogenase kinase, isozyme 2 5164 ENSG00000005882
2  ENSG00000134824 NA FADS2 fatty acid desaturase 2 9415 ENSG00000134824
3  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
4  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
5  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
6  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
7  ENSG00000072310 NA SREBF1 sterol regulatory element binding transcription factor 1 6720 ENSG00000072310
8  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
9  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
10  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
11  ENSG00000178537 NA SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 788 ENSG00000178537


Database:biological process       Name:lipid modification       ID:GO:0030258
C=145; O=8; E=0.22; R=36.69; rawP=2.18e-11; adjP=9.26e-10
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
2  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
3  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
4  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
5  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
6  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
7  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
8  ENSG00000178537 NA SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 788 ENSG00000178537


Database:biological process       Name:regulation of fatty acid metabolic process       ID:GO:0019217
C=82; O=7; E=0.12; R=56.77; rawP=2.13e-11; adjP=9.26e-10
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
2  ENSG00000005882 NA PDK2 pyruvate dehydrogenase kinase, isozyme 2 5164 ENSG00000005882
3  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
4  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
5  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
6  ENSG00000072310 NA SREBF1 sterol regulatory element binding transcription factor 1 6720 ENSG00000072310
7  ENSG00000178537 NA SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 788 ENSG00000178537


Database:biological process       Name:lipid metabolic process       ID:GO:0006629
C=1141; O=14; E=1.72; R=8.16; rawP=5.04e-11; adjP=1.90e-09
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000121691 NA CAT catalase 847 ENSG00000121691
2  ENSG00000005882 NA PDK2 pyruvate dehydrogenase kinase, isozyme 2 5164 ENSG00000005882
3  ENSG00000134824 NA FADS2 fatty acid desaturase 2 9415 ENSG00000134824
4  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
5  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
6  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
7  ENSG00000166821 NA PEX11A peroxisomal biogenesis factor 11 alpha 8800 ENSG00000166821
8  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
9  ENSG00000072310 NA SREBF1 sterol regulatory element binding transcription factor 1 6720 ENSG00000072310
10  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
11  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240
12  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
13  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
14  ENSG00000178537 NA SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 788 ENSG00000178537


Database:biological process       Name:fatty acid beta-oxidation       ID:GO:0006635
C=57; O=6; E=0.09; R=70.00; rawP=1.90e-10; adjP=6.46e-09
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
2  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
3  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
4  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
5  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
6  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315


Database:molecular function       Name:acetyl-CoA C-acyltransferase activity       ID:GO:0003988
C=6; O=3; E=0.01; R=402.21; rawP=3.25e-08; adjP=1.95e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
2  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
3  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029


Database:molecular function       Name:transferase activity, transferring acyl groups       ID:GO:0016746
C=233; O=6; E=0.29; R=20.71; rawP=2.71e-07; adjP=8.13e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
2  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
3  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
4  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
5  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
6  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240


Database:molecular function       Name:C-acyltransferase activity       ID:GO:0016408
C=15; O=3; E=0.02; R=160.88; rawP=7.34e-07; adjP=1.47e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
2  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
3  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029


Database:molecular function       Name:long-chain-3-hydroxyacyl-CoA dehydrogenase activity       ID:GO:0016509
C=2; O=2; E=0.00; R=804.42; rawP=1.46e-06; adjP=1.75e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
2  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029


Database:molecular function       Name:catalytic activity       ID:GO:0003824
C=5371; O=17; E=6.68; R=2.55; rawP=1.43e-06; adjP=1.75e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000132825 NA PPP1R3D protein phosphatase 1, regulatory subunit 3D 5509 ENSG00000132825
2  ENSG00000134824 NA FADS2 fatty acid desaturase 2 9415 ENSG00000134824
3  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
4  ENSG00000171723 NA GPHN gephyrin 10243 ENSG00000171723
5  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
6  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
7  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240
8  ENSG00000181035 NA SLC25A42 solute carrier family 25, member 42 284439 ENSG00000181035
9  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
10  ENSG00000121691 NA CAT catalase 847 ENSG00000121691
11  ENSG00000134463 NA ECHDC3 enoyl CoA hydratase domain containing 3 79746 ENSG00000134463
12  ENSG00000005882 NA PDK2 pyruvate dehydrogenase kinase, isozyme 2 5164 ENSG00000005882
13  ENSG00000119471 NA HSDL2 hydroxysteroid dehydrogenase like 2 84263 ENSG00000119471
14  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
15  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
16  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
17  ENSG00000044446 NA PHKA2 phosphorylase kinase, alpha 2 (liver) 5256 ENSG00000044446


Database:molecular function       Name:transferase activity, transferring acyl groups other than amino-acyl groups       ID:GO:0016747
C=178; O=5; E=0.22; R=22.60; rawP=2.06e-06; adjP=2.06e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
2  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
3  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
4  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
5  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029


Database:molecular function       Name:long-chain-enoyl-CoA hydratase activity       ID:GO:0016508
C=3; O=2; E=0.00; R=536.28; rawP=4.39e-06; adjP=3.76e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
2  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029


Database:molecular function       Name:carnitine O-palmitoyltransferase activity       ID:GO:0004095
C=4; O=2; E=0.00; R=402.21; rawP=8.77e-06; adjP=5.85e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
2  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184


Database:molecular function       Name:O-palmitoyltransferase activity       ID:GO:0016416
C=4; O=2; E=0.00; R=402.21; rawP=8.77e-06; adjP=5.85e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
2  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184


Database:molecular function       Name:enoyl-CoA hydratase activity       ID:GO:0004300
C=5; O=2; E=0.01; R=321.77; rawP=1.46e-05; adjP=8.76e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
2  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029


Database:cellular component       Name:mitochondrial envelope       ID:GO:0005740
C=530; O=11; E=0.75; R=14.75; rawP=4.08e-11; adjP=2.17e-09
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000121691 NA CAT catalase 847 ENSG00000121691
2  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
3  ENSG00000162461 NA SLC25A34 solute carrier family 25, member 34 284723 ENSG00000162461
4  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
5  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
6  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
7  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
8  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240
9  ENSG00000181035 NA SLC25A42 solute carrier family 25, member 42 284439 ENSG00000181035
10  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
11  ENSG00000178537 NA SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 788 ENSG00000178537


Database:cellular component       Name:mitochondrial part       ID:GO:0044429
C=744; O=12; E=1.05; R=11.46; rawP=7.27e-11; adjP=2.17e-09
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000121691 NA CAT catalase 847 ENSG00000121691
2  ENSG00000005882 NA PDK2 pyruvate dehydrogenase kinase, isozyme 2 5164 ENSG00000005882
3  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
4  ENSG00000162461 NA SLC25A34 solute carrier family 25, member 34 284723 ENSG00000162461
5  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
6  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
7  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
8  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
9  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240
10  ENSG00000181035 NA SLC25A42 solute carrier family 25, member 42 284439 ENSG00000181035
11  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
12  ENSG00000178537 NA SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 788 ENSG00000178537


Database:cellular component       Name:mitochondrion       ID:GO:0005739
C=1525; O=15; E=2.15; R=6.99; rawP=1.05e-10; adjP=2.17e-09
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000134463 NA ECHDC3 enoyl CoA hydratase domain containing 3 79746 ENSG00000134463
2  ENSG00000121691 NA CAT catalase 847 ENSG00000121691
3  ENSG00000005882 NA PDK2 pyruvate dehydrogenase kinase, isozyme 2 5164 ENSG00000005882
4  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
5  ENSG00000119471 NA HSDL2 hydroxysteroid dehydrogenase like 2 84263 ENSG00000119471
6  ENSG00000162461 NA SLC25A34 solute carrier family 25, member 34 284723 ENSG00000162461
7  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
8  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
9  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
10  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
11  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240
12  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
13  ENSG00000181035 NA SLC25A42 solute carrier family 25, member 42 284439 ENSG00000181035
14  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
15  ENSG00000178537 NA SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 788 ENSG00000178537


Database:cellular component       Name:envelope       ID:GO:0031975
C=835; O=12; E=1.18; R=10.21; rawP=2.76e-10; adjP=3.42e-09
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000121691 NA CAT catalase 847 ENSG00000121691
2  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
3  ENSG00000162461 NA SLC25A34 solute carrier family 25, member 34 284723 ENSG00000162461
4  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
5  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
6  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
7  ENSG00000072310 NA SREBF1 sterol regulatory element binding transcription factor 1 6720 ENSG00000072310
8  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
9  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240
10  ENSG00000181035 NA SLC25A42 solute carrier family 25, member 42 284439 ENSG00000181035
11  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
12  ENSG00000178537 NA SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 788 ENSG00000178537


Database:cellular component       Name:organelle envelope       ID:GO:0031967
C=822; O=12; E=1.16; R=10.37; rawP=2.30e-10; adjP=3.42e-09
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000121691 NA CAT catalase 847 ENSG00000121691
2  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
3  ENSG00000162461 NA SLC25A34 solute carrier family 25, member 34 284723 ENSG00000162461
4  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
5  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
6  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
7  ENSG00000072310 NA SREBF1 sterol regulatory element binding transcription factor 1 6720 ENSG00000072310
8  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
9  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240
10  ENSG00000181035 NA SLC25A42 solute carrier family 25, member 42 284439 ENSG00000181035
11  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
12  ENSG00000178537 NA SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 788 ENSG00000178537


Database:cellular component       Name:mitochondrial inner membrane       ID:GO:0005743
C=354; O=9; E=0.50; R=18.06; rawP=6.43e-10; adjP=6.01e-09
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000162461 NA SLC25A34 solute carrier family 25, member 34 284723 ENSG00000162461
2  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
3  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
4  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
5  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
6  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240
7  ENSG00000181035 NA SLC25A42 solute carrier family 25, member 42 284439 ENSG00000181035
8  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
9  ENSG00000178537 NA SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 788 ENSG00000178537


Database:cellular component       Name:mitochondrial membrane       ID:GO:0031966
C=508; O=10; E=0.71; R=13.99; rawP=6.79e-10; adjP=6.01e-09
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
2  ENSG00000162461 NA SLC25A34 solute carrier family 25, member 34 284723 ENSG00000162461
3  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
4  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
5  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
6  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
7  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240
8  ENSG00000181035 NA SLC25A42 solute carrier family 25, member 42 284439 ENSG00000181035
9  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
10  ENSG00000178537 NA SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 788 ENSG00000178537


Database:cellular component       Name:organelle inner membrane       ID:GO:0019866
C=384; O=9; E=0.54; R=16.65; rawP=1.32e-09; adjP=1.02e-08
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000162461 NA SLC25A34 solute carrier family 25, member 34 284723 ENSG00000162461
2  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
3  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
4  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
5  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
6  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240
7  ENSG00000181035 NA SLC25A42 solute carrier family 25, member 42 284439 ENSG00000181035
8  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
9  ENSG00000178537 NA SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 788 ENSG00000178537


Database:cellular component       Name:microbody       ID:GO:0042579
C=122; O=6; E=0.17; R=34.94; rawP=1.43e-08; adjP=8.87e-08
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
2  ENSG00000121691 NA CAT catalase 847 ENSG00000121691
3  ENSG00000166575 NA TMEM135 transmembrane protein 135 65084 ENSG00000166575
4  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
5  ENSG00000119471 NA HSDL2 hydroxysteroid dehydrogenase like 2 84263 ENSG00000119471
6  ENSG00000166821 NA PEX11A peroxisomal biogenesis factor 11 alpha 8800 ENSG00000166821


Database:cellular component       Name:peroxisome       ID:GO:0005777
C=122; O=6; E=0.17; R=34.94; rawP=1.43e-08; adjP=8.87e-08
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
2  ENSG00000121691 NA CAT catalase 847 ENSG00000121691
3  ENSG00000166575 NA TMEM135 transmembrane protein 135 65084 ENSG00000166575
4  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
5  ENSG00000119471 NA HSDL2 hydroxysteroid dehydrogenase like 2 84263 ENSG00000119471
6  ENSG00000166821 NA PEX11A peroxisomal biogenesis factor 11 alpha 8800 ENSG00000166821




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).